Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial
JP O'Reardon, HB Solvason, PG Janicak… - Biological …, 2007 - Elsevier
BACKGROUND: We tested whether transcranial magnetic stimulation (TMS) over the left
dorsolateral prefrontal cortex (DLPFC) is effective and safe in the acute treatment of major
depression. METHODS: In a double-blind, multisite study, 301 medication-free patients with
major depression who had not benefited from prior treatment were randomized to active (n=
155) or sham TMS (n= 146) conditions. Sessions were conducted five times per week with
TMS at 10 pulses/sec, 120% of motor threshold, 3000 pulses/session, for 4–6 weeks …
dorsolateral prefrontal cortex (DLPFC) is effective and safe in the acute treatment of major
depression. METHODS: In a double-blind, multisite study, 301 medication-free patients with
major depression who had not benefited from prior treatment were randomized to active (n=
155) or sham TMS (n= 146) conditions. Sessions were conducted five times per week with
TMS at 10 pulses/sec, 120% of motor threshold, 3000 pulses/session, for 4–6 weeks …
